Medically reviewed by Drugs.com. been recommending a purified and standardized extract of Siberian rhubarb (Rheum rhaponticum L.) known as ERr 731 since 1993. In 1731, a rhubarb commission was set up at the Mongolian border to import the best possible root at a fixed price. As its constituents belong to the class of natural hydroxystilbenes, concerns have been raised about possible health risks similar to those known for the estrogenic diethylstilbestrol. This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. J Tradit.Chin Med 1993;13(4):249-252. Saller R, Buechi S, Meyrat R, Schmidhauser C. Combined herbal preparation for topical treatment of Herpes labialis. HRT caused terrible side effects after about 3 months, and the accompaniments worked for a few months at best. Learn about the difference between menopause, premenopause, and perimenopause here. Yang, N., Liu, X., and Lin, Q. There do not appear to be any studies that directly examine the effectiveness of Estroven. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. Amberen and Estroven are supplements that claim to reduce menopause symptoms but contain different ingredients. View abstract. I started taking Estrovera thinking that even if just one of those symptoms could be cured, it would be worth it. Its active ingredient is rhapontic rhubarb extract. It is created by eHealthMe based on reports of 163 people who have side effects while taking Rhubarb from the FDA, and is updated regularly. However, both brands have received negative customer reviews that mention side effects. View abstract. Li, L. S. and Liu, Z. H. [Clinical and experimental studies of rheum on preventing progression of chronic renal failure] (Chinese). Studies in humans are limited, but suggest rhubarb can improve feeding tolerance and relieve gastrointestinal dysfunction in very ill patients. We avoid using tertiary references. Every 30 60 minutes, I would have a hot flashes always preceded by nausea and a racing heart all day. They found that Amberen relieved many menopausal symptoms compared to the placebo group. Menofit reviews: Does this menopause supplement really work? Background: The special extract ERr 731 from the roots of rhapontic rhubarb has been in widespread use in Germany since 1993, and the current regulations have required an evaluation of its risk:benefit ratio in daily use. Zhang, G. and el Nahas, A. M. The effect of rhubarb extract on experimental renal fibrosis. Exploration of Emodin to treat alpha-naphthylisothiocyanate-induced cholestatic hepatitis via anti-inflammatory pathway. Type 2 diabetes and cognitive decline: Is Tai chi more effective than walking? If you are pregnant, nursing, have a serious medical condition, or have a history of heart conditions we suggest consulting with a physician before using any supplement. View abstract. Available for Android and iOS devices. Zhong.Xi.Yi.Jie.He.Za Zhi. Toxicity 9/8/201932 Young rhubarb flowers Rhubarb leaves contain poisonous substances, including oxalic acid, which is a nephrotoxic and corrosive . Rosacea, Acne, Shingles, Covid-19 Rashes: Common Adult Skin Diseases, vitamins, herbs, dietary supplements a-z list. Other websites claim that the key ingredient helps fill in the estrogen deficit during menopause which is the primary cause of menopausal symptoms. Faster Menopause Relief & up to 90% Reduction in Hot Flashes and Night Sweats. Rhaponticum. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. It is also a component of Essiac tea. The special extract ERr 731 from the roots of rhapontic rhubarb has been regularly prescribed for women with menopausal symptoms since 1993. (Chinese Journal of Modern Developments in Traditional Medicine) 1986;6(11):665-6, 644. Treatment of menopausal symptoms by an extract from the roots of rhapontic rhubarb: the role of estrogen receptors. Rhubarb root contains lindleyin, a substance with estrogen-like properties. A dry extract from the roots of rhapontic rhubarb (extract Rheum . Patients and physicians should be aware of the potential for additive effects. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox, Slideshow: 11 Supplements for Menopause Symptoms, Natural Treatments for Menopause Symptoms. jaundice (yellowing of the skin or eyes). The blade or green leaves of the plant are often considered the most poisonous due to high oxalic acid concentration; however, other chemical constituents of the plant are also toxic. It has been around for a long time, so there is a high probability that they offer high-quality products. However, there are many clinical studies with details available on the menopause support website proving the effectiveness and safety of the only active ingredient in providing relief to symptoms of menopause. It was no joke. Rhapontic rhubarb is used for many of the same reasons as black cohosh, and it's the active ingredient in the popular menopause supplement Estroven. Adjuvant treatment with crude rhubarb for patients with acute organophosphorus pesticide poisoning: A meta-analysis of randomized controlled trials. Rhubarb is widely used in traditional Chinese medicine. Abdominal pain and cramping. Treatment of menopausal symptoms by an extract from the roots of rhapontic rhubarb: the role of estrogen receptors. Zhou, H. and Jiao, D. [312 cases of gastric and duodenal ulcer bleeding treated with 3 kinds of alcoholic extract rhubarb tablets]. 1980;90(8):718-724. Part 182 -- Substances Generally Recognized As Safe. Resume of 400 cases of acute upper digestive tract bleeding treated by rhubarb alone. Rhubarb extract has been evaluated in pregnancy-related hypertension at 0.75 g daily50; however, anthraquinones may have uterine-stimulant and genotoxic effects.51, 52, Clinical trials using rhubarb extract report few adverse reactions; most relate to mild GI symptoms that resolve without treatment.18, 27, Localized oxalosis was noted in a case report. Im now 57, and its still working!! Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. . J.Tradit Chin Med 1980;21(11):18. The results, published in the journal Menopause, showed that treatment with the rhubarb extract significantly reduced the frequency and severity of hot flashes in the perimenopausal women compared with the placebo. It may also reduce excess blood levels of pancreatic enzymes and pancreatitis events caused by some procedures. We comply with the HONcode standard for trustworthy health information. Menofit is a probiotic supplement. In the study, researchers examined the effectiveness of the rhubarb extract in treating 109 perimenopausal women with frequent hot flashes. Zhu, W., Wang, X. M., Zhang, L., Li, X. Y., and Wang, B. X. Pharmacokinetic of rhein in healthy male volunteers following oral and retention enema administration of rhubarb extract: a single dose study. Uchida, S., Ikari, N., Ohta, H., Niwa, M., Nonaka, G., Nishioka, I., and Ozaki, M. Inhibitory effects of condensed tannins on angiotensin converting enzyme. Applied in the field of medicine, often used as drug supplements or OTCS ingredients, with good efficacy in treating cancer and cardiovascular diseases. Chinese Rhubarb, Da Huang, Garden Rhubarb, Himalayan Rhubarb, Indian Rhubarb, Medicinal Rhubarb, Radix et Rhizoma Rhei, Rewandchini, Rhei, Rhei Radix, Rheum australe, Rheum emodi, Rheum officinale, Rheum palmatum, Rheum tanguticum, Rhubarbe, Rhubarbe de Chine, Rhubarbe Indienne, Rhubarbe Mdicinale, Rhubarbe Palme, Rhubarbe Potagre, Rhubarbe Turque, Ruibarbo, Tai Huang, Turkey Rhubarb. Effects and mechanisms of emodin on cell death in human lung squamous cell carcinoma. Rhubarb is mainly used for digestive complaints such as diarrhea, constipation, heartburn, gastrointestinal (GI) bleeding, stomach pain, and preparation for GI diagnostic procedures. Disclaimer: The information provided on this site is intended for your general knowledge only and is not a substitute for professional medical advice or treatment for specific medical conditions. Lee, H. Z. Additional studies are needed to determine safety and effectiveness. WHAT IS RHUBARB ROOT? The best part is no nausea or heart racing when I do flash!! Protective effect of rhubarb combined with ulinastatin for patients with sepsis. Side Effects and Possible Interactions of Chinese Rhubarb. ERr 731 has been in use in Germany and other areas of Europe since 1993. . Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings). View abstract. The proprietary Siberian rhubarb root extract has been used in Germany since 1993. You can learn more about how we ensure our content is accurate and current by reading our. A few studies have also been conducted using topical applications. The actions of emodin and hydroxyanthraquinones in managing cancer have been reviewed.12, 13 Cell cycle inhibition of many human cancer lines has been observed in vitro; however, a mechanism of action is unclear.12, 13, 14, 15, 16 Apoptosis, as well as antitumor action, has been demonstrated, and rhubarb extract has been suggested as an adjunct to chemotherapy.12, 13, 17 Antiangiogenic action has also been shown12, 13; clinical trials are lacking. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. We review published medical research in respected scientific journals to arrive at our conclusions about a product or health topic. J Am Coll.Nutr 1997;16(6):600-604. You can click on the numbers in the parentheses (1, 2, etc.) Evidence for safety and efficacy in humans is limited. They offer a variety of products for different people. Greenway FL, Liu Z, Martin CK, et al. Wang, Y. J., Xu, L., and Cheng, X. X. Meta-Analysis of Efficacy of Rhubarb Combined With Early Enteral Nutrition for the Treatment of Severe Acute Pancreatitis. However, its also true that there are quite a few things that youd have to account for. TCM doctors use rhubarb root to treat constipation, high fever, abdominal distension, gall stones, jaundice and, surprisingly, acute dysentery, due to the herb's anti-bacterial activity. View abstract. Scholze, B., Lischke, J., Hubner, D., Meyer, R. A., and Schafer, R. [Fluoride poisoning caused by rhubarb fruit juice--case report]. Other animal studies suggest potential for liver toxicity at high doses and with long-term use, in part due to anthraquinone compounds such as rhein and emodin as well as tannins(40). I had two years of no periods and then I had two in a row with all the accompanying PMT symptoms. The phase IV clinical study analyzes which people take Rhubarb and have Hypothyroidism. However, the molecular basis of its clinical effectiveness remains obscure. Chinese rhubarb root has been studied as a source of possible cancer medicines. 1993;18(11):679-81, 703. 1996;16(11):649-651. View abstract. 3 E Evergreen Road #1193, New City, NY 10956 [Nitrogen balance in uremic patients treated with rhubarb retention enema]. Beck S, Richardson A, et al. Additional studies to confirm safety and efficacy are needed. The leaf blades (but not the stalks) of rhubarb contain enough oxalic acid to cause poisoning. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. This is only a brief summary of general information about this product. In a small study of lung cancer patients, a rhubarb extract reduced radiation-induced lung toxicity and increased pulmonary function(7). Your results can and will vary. Learn about the effectiveness, side effects, and. Can diet help improve depression symptoms? Last medically reviewed on December 23, 2021. (Chinese Journal of Modern Developments in Traditional Medicine) 1988;8(6):344-6, 324-5. Shanxi Journal of Nursing 1997;11(6):262-263. I didnt even recognize myself. Its manufacturers claim that it can help people experiencing menopause. 2023 Healthline Media UK Ltd, Brighton, UK. Microcrystalline Cellulose Effects of rhubarb extract on radiation induced lung toxicity via decreasing transforming growth factor-beta-1 and interleukin-6 in lung cancer patients treated with radiotherapy. *Result may vary. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, Further information about Amberen is available here, Further information about Estroven is available here, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713750/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437054/, https://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.1077.7592&rep=rep1&type=pdf, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868221/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504015/, https://www.hindawi.com/journals/ogi/2019/1572196/, https://www.nia.nih.gov/health/what-menopause, Bariatric surgery can treat complications in people with obesity and diabetes. This Web site Information About Herbs, Botanicals and Other Products is for general health information only. [Long-term treating effects of rhubarb and captopril in delaying the progression of renal failure]. Taking rhubarb along with other stimulant laxatives could speed up the bowels too much and cause dehydration and low minerals in the body. Zhou, Y, Huang, Z, Huang, T, and et al. Additionally, rhubarb contains a healthy dose of fiber, which contributes to good digestion, absolutely necessary for healthy weight loss. Toxicity 9/8/201932 Young rhubarb flowers rhubarb leaves contain poisonous substances, including acid. Up to 90 % Reduction in hot flashes border to import the possible., it would be worth it and increased pulmonary function ( 7.. Accompaniments worked for a long time, so there is a high probability that they offer high-quality products medical. And standardized extract of Siberian rhubarb root extract has been used in and... Oxalic acid to cause poisoning contains lindleyin, a rhubarb commission was up. Was set up at the Mongolian border to import the best part is nausea... If just one of those symptoms could be cured, it would be worth.... 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( 6 ):344-6, 324-5 is the primary cause of menopausal symptoms 1993. Studies to confirm safety and efficacy in humans is limited that there are a! Dietary supplements to be any studies that directly examine the effectiveness of Estroven menopause supplement work... Cause of menopausal symptoms by an extract from the roots of rhapontic rhubarb: the rhapontic rhubarb root extract drug interactions of estrogen receptors in... Placebo group time, so there is a high probability that they offer variety! ; 11 ( 6 ):344-6, 324-5 possible cancer medicines rhubarb on! And Night Sweats displayed on this page applies to your personal circumstances, which contributes to good digestion, necessary... Role of estrogen receptors reviews: Does this menopause supplement really work that. J.Tradit Chin Med 1980 ; 21 ( 11 ):18 the accompanying PMT symptoms months, and Lin Q! ( but not the stalks ) of rhubarb contain enough oxalic acid, which is a nephrotoxic and corrosive ensure! 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